Physiologic Effects of Intra-nasal Sedation with Midazolam and Ketamine in 3-6 Years old Uncooperative Children
نویسندگان
چکیده مقاله:
Objective: Several medications have been used for sedation in children in dentistry and intra-nasal route has been reported to be an efficient way regarding patient cooperation. The aim of the present study was to compare the changes in physiologic parameters following intra-nasal midazolam and ketamine administration. Methods: In this randomized cross-over double-blind trial, 17 uncooperative 3-6 years old children requiring at least two dental treatments were selected randomly and received intra-nasal ketamine (0.5 mg/kg) and midazolam (0.2 mg/kg) prior to the treatment using the other drug in the next visit. Physiologic parameters including blood pressure, heart rate, respiratory rate and O2 saturation were measured and compared during the different time intervals using two way repeated measure ANOVA. Results: The patients showed higher blood pressure and heart rate following ketamine administration compared to midazolam (p<0.001). No significant difference was found between the drugs at different time intervals regarding respiratory rate and O2 saturation. (p> 0.05) Conclusion: In spite of significant differences between midazolam and ketamine regarding heart rate and blood pressure, both drugs can b e used as effective sedative medications without treatment interruption in children.
منابع مشابه
physiologic effects of intra-nasal sedation with midazolam and ketamine in 3-6 years old uncooperative children
objective: several medications have been used for sedation in children in dentistry and intra-nasal route has been reported to be an efficient way regarding patient cooperation. the aim of the present study was to compare the changes in physiologic parameters following intra-nasal midazolam and ketamine administration. methods: in this randomized cross-over double-blind trial, 17 uncooperativ...
متن کاملComparison of Oral and Intranasal Midazolam/Ketamine Sedation in 3-6-year-old Uncooperative Dental Patients
Background and aims. There are several known sedative drugs, with midazolam and ketamine being the most commonly used drugs in children. The aim of this study was to compare the effect of intranasal and oral midazolam plus ketamine in children with high levels of dental anxiety. Materials and methods. A crossover double-blind clinical trial was conducted on 23 uncooperative children aged 3-6 (n...
متن کاملcomparison of oral and intranasal midazolam/ketamine sedation in 3‒6-year-old uncooperative dental patients
background and aims. there are several known sedative drugs, with midazolam and ketamine being the most com-monly used drugs in children. the aim of this study was to compare the effect of intranasal and oral midazolam plus ket-amine in children with high levels of dental anxiety. materials and methods. a crossover double-blind clinical trial was conducted on 23 uncooperative children aged 3‒6 ...
متن کاملEffect of intranasal midazolam with/without inhalation sedation (N2O/O2) in 3‒6-year-old uncooperative dental patients
Introduction: Due to incomplete development of coping skills in children, they usually cannot cope with stressful situations like dental appointments. The present study aims to evaluate the effect of intranasal midazolam with/without inhalation sedation (N2O/O2) in children with high levels of dental anxiety. Materials and Methods: This crossover double-blinded clinical trial was conducted on 1...
متن کاملeffect of intranasal sedation using ketamine and midazolam on behavior of 3-6 year-old uncooperative children in dental office: a clinical trial
objectives: the aim of the present study was to compare the effects of intranasal ketamine and midazolam on behavior of 3-6 year-old children during dental treatments. materials and methods: in this randomized cross-over clinical trial, 17 uncooperative children requiring at least two dental treatments were selected and randomly received ketamine (0.5mg/kg) or midazolam (0.2mg/kg) prior to tr...
متن کاملEffect of Intranasal Sedation Using Ketamine and Midazolam on Behavior of 3–6 Year-Old Uncooperative Children in Dental Office: A Clinical Trial
OBJECTIVES The aim of the present study was to compare the effects of intranasal ketamine and midazolam on behavior of 3-6 year-old children during dental treatments. MATERIALS AND METHODS In this randomized cross-over clinical trial, 17 uncooperative children requiring at least two dental treatments were selected and randomly received ketamine (0.5mg/kg) or midazolam (0.2mg/kg) prior to trea...
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عنوان ژورنال
دوره 33 شماره None
صفحات 59- 65
تاریخ انتشار 2015-03
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